Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Oncol. doi: 10.1016/j.ygyno.2006.10.047, Shah, A. C., Minturn, J. E., Li, Y., Belasco, J. Emetogenicity of Chemotherapy : MASCC/ESMO Guidelines - EMJ (2016). During the study period, our institution applied carboplatin (including carboplatin with cyclophosphamide or paclitaxel) as the front-line chemotherapy for women with ovarian, fallopian tube, and primary peritoneal cancer. The annual incidence of carboplatin-related hypersensitivity reactions in 735 women with ovarian, fallopian tube, or primary peritoneal cancers. Necessary cookies enable core functionality. Markman et al. All of these reported symptoms and signs occurred within an hour of initiating carboplatin administration. Lancet 361, 20992106. We retrospectively recruited all women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with single-agent carboplatin or a carboplatin-based combination chemotherapy regimen at National Taiwan University Hospital from January 2006 to December 2013. doi: 10.3802/jgo.2013.24.4.342, Confino-Cohen, R., Fishman, A., Altaras, M., and Goldberg, A. The https:// ensures that you are connecting to the Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines. This site uses cookies. Assess for pustules or blisters or erosions in addition to areas of "dusky erythema" which may feel painful to palpation. Supportive and Palliative Care | ESMO Prior investigations reported that a history of drug allergies correlates with the incidence of carboplatin-related hypersensitivity reactions (Libra et al., 2003; Sliesoraitis and Chikhale, 2005). An official website of the United States government. 2017 Jun 20;18(6):1316. doi: 10.3390/ijms18061316. 57 . Several methods have been developed to prevent carboplatin-related hypersensitivity reactions (Libra et al., 2003; Confino-Cohen et al., 2005; Gomez et al., 2009; Greene et al., 2010; Takase et al., 2015; Shah et al., 2016). The yearly incidence of carboplatin-related hypersensitivity gradually increased from 0.88 in 2006 to 5.42% in 2013 (Table 1), in association with increased use of carboplatin. Multivariate analysis was conducted using logistic regression to estimate the association between the potential risk factors and the occurrence of hypersensitivity. Symptoms and signs of 75 patients with hypersensitivity reactions to carboplatin. ESMO Virtual Congress 2020 | OncologyPRO CA. Figure 1. 84, 378382. Monitor. Prior to an infusion of a mAb, nurses should do the following (Olsen et al., 2019): . Severe reactions are less frequent and may be fatal without appropriate intervention. Women are more affected by drug allergy and up to 27% of women with ovarian and breast cancer develop carboplatin allergy after multiple cycles of treatment. Ovarian cancer is the leading cause of death from gynecological malignancies (Chiang et al., 2013), with a 5-year survival rate of 46% in the United States (92% when localized, 73% with regional metastases, and 28% with distant metastases) (Siegel et al., 2016). Summary format including algorithms, figures andtables for your presentations. Haanen JBAG, Carbonnel F, Robert C, Kerr KM, Peters S, Larkin J, Jordan K; ESMO Guidelines Committee. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Arnall JR, Moore DC, Hill HL, Griffin S, Mueller MK, Lavery LA, Voorhees PM, Usmani SZ. WHIPPANY, N.J., Sept. 1, 2017 /PRNewswire/ -- Bayer will present the latest research from across its growing oncology portfolio at the European Society for Medical Oncology (ESMO) 2017 Congress . Reactions to taxenes including paclitaxel and docetaxel present with pain as a neuromuscular symptoms in up to 4% of the patients. LUGANO-MADRID, 09 September, 2017 -The preliminary results of a study to be presented at the ESMO 2017 Congress in Madrid (1) show that socio-psychological factors have become more significant for . Rapid drug desensitization for hypersensitivity reactions to chemotherapy and monoclonal antibodies in the 21st century. Have a look to the ESMO 2017 Programme online! doi: 10.1016/j.ygyno.2007.06.016, Markman, M., Kennedy, A., Webster, K., Elson, P., Peterson, G., Kulp, B., et al. (2010). The rate of hypersensitivity was significantly higher among patients with advanced stage disease (IIIIV) compared to patients with early stage disease (III) (P < 0.001, Kruskal-Wallis test), and among patients with serous or mixed histological type compared to patients with other histological types (P = 0.003, Kruskal-Wallis test). Table 4. Chan. The ESMO guideline recommends patients receive surveillance by colonoscopy every 3 years beginning at age 25 for MLH1 and MSH2 mutation carriers and age 35 for MSH6 and PMS2 mutation carriers, or . doi: 10.1093/annonc/mdt333. (2011) found that the number of treatment cycles with platinum-containing antineoplastic agents significantly correlates with the incidence of related hypersensitivity reactions. Supportive and Palliative Care | ESMO Management of Infusion Reactions to Systemic Anticancer Therapy: ESMO Clinical Practice Guidelines Published in 2017 - Ann Oncol (2017) 28 (suppl 4): iv100-iv118. FOIA Incidence and Management of Olaratumab Infusion-Related Reactions. Int J Mol Sci. Ke. Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: The Role of Desensitizations Front Immunol. ESMO 2017 was held in partnership with the European Association for Cancer Research (EACR) in Madrid . Int. Invest. The tests were analyzed at an accredited lab according to protocol. Accessibility The comparison between other countries and ours about characteristics of the patients receiving carboplatin-based chemotherapy and risk factors of carboplatin-related hypersensitivity reactions. 2022 Dec;11(12):1405-1418. doi: 10.1002/cpdd.1183. Pharmacol. It would be worthwhile to design a perspective trial that could randomize patients with carboplatin hypersensitivity to receive an alternative regimen without carboplatin. S.M. Symptoms and signs of hypersensitivity reactions amendable to desensitization. 2022 May 20;12:879391. doi: 10.3389/fonc.2022.879391. See this image and copyright information in PMC. These differences were likely related to the fact that patients with advanced disease, serous carcinoma, and ascetic malignant cells required significantly more carboplatin treatment cycles and higher carboplatin doses. Sixty-one of these patients were re-challenged with carboplatin following their initial hypersensitivity reaction. Do Steroids Matter? A Retrospective Review of Premedication for Taxane Acquisition of data: Y-HT, S-PL, Y-CC, Y-LC. 105, 14721479. Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report. All funding for this site is provided directly by ESMO. Does the platinum-free interval predict the incidence or severity of hypersensitivity reactions to carboplatin? Front. Timetrend analyses showed that most events were reported during the first 68 cycles with concurrent chemotherapy, with a decrease in later cycles (except MetaPHER). Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. eCollection 2017. Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: An intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG. J. Clin. (2009). (2017). Oncol. (2005) reported that all carboplatin-associated hypersensitivity reactions occur in patients with prior carboplatin exposure, and Tamiya et al. Read guidelines by topic Latest Guidelines News Cancer 20, 385393. A sincere thanks to the almost 24,000 participants who attended this year's annual congress! Interactive/Pocket Guideline Interactive/Pocket Guideline Constipation in Advanced Cancer 1 2 3 Galateanu B, Pucau AI, Tircol SA, Tanase BC, Hudita A, Negrei C, Burcea-Dragomiroiu GT, Negreanu L, Vacaroiu IA, Ginghin O. Int J Mol Sci. A., Colombo, N., du Bois, A., Delaloye, J. F., Kristensen, G. B., et al. de Las Vecillas Snchez L, Alenazy LA, Garcia-Neuer M, Castells MC. Incidence and intensity of anaphylaxis/hypersensitivity events: Table: 138P Discontinuations due to anaphylaxis/hypersensitivity were rare for PH IV (generally <1% except two TRYPHAENA arms: 1% and 3%); no discontinuations of PH FDC SC have been recorded so far. 8600 Rockville Pike Management of toxicities from immunotherapy: ESMO Clinical Practice We retrieved clinical information, including age, menopausal status, cancer stage, surgical findings, chemotherapeutic treatment history, recurrence status, and survivorship, from the clinical and operative notes and discharge summaries stored in a centralized database. Necessary cookies enable core functionality. ESMO is a Swiss-registered not-for-profit organisation. Lacouture, V. Sibaud, P.A. To overcome drug allergy, desensitization has been developed, a novel approach which provides a unique opportunity to protect against anaphylaxis and to improve clinical outcomes. Before Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Webcasts and presentations from ESMO 2017 can be accessed by ESMO members and event attendees. Cancer 63, 2126. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Expert Opin Drug Saf (2003) 2(6):597607.10.1517/14740338.2.6.597 Close monitoring is warranted for patients with any one of these three risk factors who are receiving carboplatin. The site is secure. ESMO is a Swiss-registered not-for-profit organisation. doi: 10.1111/cas.12538, Kandel, M. 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Hoffmann-La Roche Ltd. H. Macharia: Non-Financial Interests, Personal, Research Grant, Medical writing support: F. Hoffmann-La Roche Ltd.; Financial Interests, Personal, Full or part-time Employment: F. Hoffman-La Roche. doi: 10.1016/j.ygyno.2006.04.002, Ozols, R. F., Bundy, B. N., Greer, B. E., Fowler, J. M., Clarke-Pearson, D., Burger, R. A., et al. 28, 33233329. J. Gynecol. We found a higher incidence of carboplatin-related hypersensitivity among patients with advanced disease (stage IIIIV) with serous carcinoma and malignant ascites. (2009). Doxorubicin/adriamycin and other chemotherapies present with sudden onset hypo or hypertension in up to 60% of patients and rituximab and other monoclonal antibodies present with cutaneous and cardiovascular symptoms in 70% of the patients. Front Oncol. van de Loosdrecht, Arjan A. Cancer. The overall safety of desensitization for common chemotherapy drugs and monoclonal antibodies. The term 'hypersensitivity' should be used to describe objectively reprodu- cible symptoms or signs initiated by exposure to a dened stimu- lus at a dose tolerated by normal persons. However, 48 (78.7%) of these patients developed repeated hypersensitivity reactions, even after pre-treatment with intravenous antihistamines, H2 blocker, and corticosteroids prior to carboplatin re-administration. http://downloads.hindawi.com/journals/mbd/2010/207084.pdf, Kadoyama K, Kuwahara A, Yamamori M, Brown JB, Sakaeda T, Okuno Y. Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS. The experience from Women and Infants' Hospital. Discontinuations due to anaphylaxis/hypersensitivity were rare for PH IV (generally <1% except two TRYPHAENA arms: 1% and 3%); no discontinuations of PH FDC SC have been recorded so far. Epub 2011 Jan 26. Life expectancy for cancer patients allergic and desensitized to carboplatin and non-allergic to, MeSH Management of infusion reactions to systemic anticancer therapy: ESMO Bookshelf The MASCC/ESMO guidelines recommend that patients receiving HEC are given a dose of 20 mg dexamethasone on Day 1 to prevent acute emesis; however, if the NK 1 RAs aprepitant or netupitant are also used, a reduced dose of 12 mg dexamethasone is recommended. The dilemma of carboplatin-associated hypersensitivity reactions in ovarian cancer management. In the US, PH FDC SC can be administered by healthcare professionals in patients (pts) homes. A video magazine about the congress, highlighting the most important information about the event. For more detailed information on the cookies we use, please check our Privacy Policy. A prospective single-center study. Check the latest publications and updates here to make sure you dont miss anything. Anaphylaxis and hypersensitivity in trials of intravenous pertuzumab J Oncol Pract. and transmitted securely. Login to your ESMO accountto sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. ESMO is a Swiss-registered not-for-profit organisation. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. doi: 10.1007/s00520-011-1123-y, Gomez, R., Harter, P., Lck, H. J., Traut, A., Kommoss, S., Kandel, M., et al. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. Death from anaphylaxis to cisplatin: a case report. Disclaimer. Oncol. General Information | ESMO 2017 Successful carboplatin desensitization in patients with proven carboplatin allergy. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Monitor. Pediatric. Copyright 2017 Tai, Tai, Hsu, Lee, Chen, Chiang, Chen, Chen and Cheng. Cisplatinum rechallenge in relapsed ovarian cancer patients with platinum reinduction therapy and carboplatin hypersensitivity. Access all the congress resources: webcasts, news, press, posters, videos and much more. doi: 10.1111/IGC.0b013e3181a418ff, Greene, D. P., Ferriss, J. S., and Jazaeri, A. Oncol. 2017 Jul 1;28(suppl_4):iv119-iv142. Gerber, C. van den Hurk, P. Fernndez-Peas, D. Santini, F. Jahn, K. Jordanon behalf of the ESMO Guidelines Committee. The cumulative incidence of carboplatin-related hypersensitivity was 2% at >3,500 mg, 6% at >7,500 mg, 8% at >10,000 mg, and 10% at >16,000 mg with a plateau beyond this dose (Figure 1B). Clipboard, Search History, and several other advanced features are temporarily unavailable. Federal government websites often end in .gov or .mil. In addition, the development of a new generation of platinum cytotoxic drugs to avoid hypersensitivity reactions is warranted. Optimal debulking surgery was performed in 491 patients (66.8%). Platinum agent-induced hypersensitivity reactions: data mining of the public version of the FDA adverse event reporting system, AERS. E. Restuccia: Financial Interests, Personal, Full or part-time Employment: F. Hoffmann-La Roche Ltd.; Financial Interests, Personal, Stocks/Shares: Genentech, Inc; Non-Financial Interests, Personal, Research Grant, Medical writing support: F. Hoffmann-La Roche Ltd. S. 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Hoffmann-La Roche Ltd.; Financial Interests, Institutional, Advisory Board: MSD. It would be worthwhile to evaluate the correlation between other HRD genes and carboplatin hypersensitivity. desensitization; drug allergy; monoclonal antibodies in cancer; platins; taxanes. 2008;14(27):2892-901. doi: 10.2174/138161208786369803. Tx-nave pts ORR was 90%. 2022 Jun 16;3:868300. doi: 10.3389/falgy.2022.868300. 'Allergy' is a hypersensitivity reaction (HSR) initiated by specic immunolo- gical mechanisms.
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